INTRODUCTION

Glimidoxt M 2 Tablet PR belongs to a category of medicines known as anti-diabetic drugs. It is a combination of two medicines used to treat type 2 diabetes mellitus in adults. It helps control blood sugar levels in people with diabetes.

Glimidoxt M 2 Tablet PR should be taken with food. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to how it is working according to your blood sugar levels.

Keep taking this medicine, even if you feel well or your blood sugar levels are controlled. If you stop it without consulting your doctor, your blood sugar levels could rise and put you at risk of kidney damage, blindness, nerve problems and loss of limbs. Remember that it is only part of a treatment program that should also include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Your lifestyle plays a big part in controlling diabetes.

The most common side effect of Glimidoxt M 2 Tablet PR is low blood glucose levels (hypoglycemia). Make sure you recognize the signs of having low blood glucose levels, such as sweating, dizziness, headache, and shaking and know how to deal with it. To prevent this, it’s important to have regular meals and always carry a fast-acting source of glucose such as sugary food or fruit juice with you. Drinking alcohol can also increase your risk of low blood sugar levels and should be avoided. Other side effects that may be seen on taking this medicine include taste changes, nausea, diarrhea, stomach pain, headache and upper respiratory tract infection. Some people may find that they put on weight with this medicine.

You should not take it if you have type 1 diabetes mellitus, if you have diabetic ketoacidosis (high levels of acid in your blood), or if you have severe kidney or liver disease. Before taking this medicine, tell your doctor if you have ever had heart disease. It may not be suitable. Pregnant or breastfeeding women should also consult their doctor before taking it. Your blood sugar levels should be checked regularly and your doctor may also advise blood tests to monitor your blood cell counts and liver function.

USES OF GLIMIDOXT M TABLET PR

• Type 2 diabetes mellitus

Type 2 diabetes mellitus

Description of Type 2 diabetes mellitus

Definition

Type 2 diabetes (also known as non-insulin dependent diabetes or adult onset diabetes) is a disease in which the blood glucose levels in the body stay consistently above normal. Insulin is the hormone which regulates blood glucose levels. Insulin is produced in the body by the pancreas. It regulates glucose levels in your blood by numerous mechanisms. In case of diabetes, the body may have a deficiency of insulin or resistance to action of insulin at the tissue level, or both.

Causes and Risk Factors

Common causes and risk factors of Type 2 diabetes are:

1. Genetic factors: You are at an increased risk of suffering from diabetes if either of your parents, grandparents, or siblings has it.

2. Factors present at birth: Low birth weight is associated with type 2 diabetes later in life.

3. Age: As you age, the chances of suffering from diabetes also increases, especially after 45 years.

4. Fat distribution: Increased fat stores in abdominal area, increases your risk of Type 2 diabetes.

5. Obesity: Increased weight is a major risk factor for diabetes.

6. Lack of exercise: Inactivity leads to weight gain and increased fat storage in your body and thus increases the risk of diabetes.

7. Smoking

8. Diet: A low fiber, high fat, and sugary diet can lead to weight gain and eventually, diabetes.

9. Stress

Signs and Symptoms

The common signs and symptoms of diabetes include:

1. Increased frequency and quantity of urination

2. Increased thirst

3. Weight loss 

4. Blurred vision 

5. Fatigue

6. Skin Infections

Investigations

Investigations include:

1. Blood sugar fasting and post lunch: Blood glucose levels checked on empty stomach, i.e., overnight fasting for about 8 to 12 hours and then 2 hours after lunch. This forms the basic routine check for diabetes in any patient.

2. HbA1C (glycosylated hemoglobin): Is the test that gives you an average estimate of blood glucose levels over the span of last 3 months.

3. Glucose tolerance test: It helps in diagnosing diabetes in patients who have fasting glucose on higher side. This test measures body’s ability to utilize the given amount of glucose when consumed orally.

Other investigations that might be done are urine for protein, complete blood count, urea and electrolytes, lipid profile and liver function test.

Treatment

There are various drugs available in the market to treat type 2 diabetes. They depend upon the cause of diabetes, severity of the disease, and presence or absence of any other diseases your doctor would prescribe you drugs like oral hypoglycemics or insulin.

Complications and When Should You See a Doctor

You must regularly visit your doctor, follow the treatment as prescribed and get all the investigations done whenever advised, for timely diagnosis of various complications of type 2 diabetes.

1. Cardiovascular (heart) diseases

2. Diabetic nephropathy: Uncontrolled diabetes disrupts the functioning of the kidneys. Severe damage to kidney can result in kidney failure or irreversible kidney damage.

3. Diabetic neuropathy: Persistent high blood glucose levels injure the nerves, especially of the legs and arms. This is termed as diabetic neuropathy. This results in tingling, numbness, burning, or pain beginning from tip of the toes or fingers and slowly spreads upward. This is therefore called ‘socks and gloves’ pattern. Uncontrolled diabetes can ultimately result in loss of different types of sensation, like temperature, pressure, pain, vibration sensation, etc. in the affected limbs.

4. Diabetic retinopathy: Diabetes damages the blood vessels of retina which if not treated in time can result in blindness.

5. Foot damage: Foot damage due to nerve damage and reduced blood supply to the lower limbs is called diabetic foot. It is the result of uncontrolled diabetes and can ultimately lead to amputation of affected toe or foot.

6. Infections

BENEFITS OF GLIMIDOXT M TABLET PR

In Type 2 diabetes mellitus

Glimidoxt  M 2 Tablet PR is a combination medicine that increases the amount of insulin your body produces (in the pancreas). The insulin then works to lower your blood glucose level. It is usually taken once a day. You should keep taking it for as long as it is prescribed.
Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life.

SIDE EFFECTS OF GLIMIDOXT M TABLET PR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Glimidoxt M

• Hypoglycemia (low blood glucose level)
• Taste change
• Nausea
• Diarrhea
• Stomach pain
• Headache
• Upper respiratory tract infection

HOW TO USE GLIMIDOXT M TABLET PR

Use it as advised by your doctor or check the label for directions before use. Glimidoxt M 2 Tablet PR is to be taken with food.

HOW GLIMIDOXT M TABLET PR WORKS

Glimidoxt M 2 Tablet PR is a combination of two antidiabetic medicines: Glimepiride and Metformin. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide which works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body’s sensitivity to insulin.